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KMID : 0616619970030010167
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Journal of Soonchunhyang Medical College
1997 Volume.3 No. 1 p.167 ~ p.172
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A Study for Effect of Bile of Cyprinus Carpio on Human Liver
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Abstract
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To investigate the effect of Cyprinus carpio bile acid on human liver, concentrated and 10:1 diluted Cyprinus carpio bile acid were injected at the dose of 10ul at mouse tail vein One, three, five, seven and nine days after injection, the mice were sarcificed.
The change in hepatic function were estimated by determining GOT, GPT and compared to histologic findings of liver tissue.
The results of GOT level was not consistent, but the GPT was significant.
From these, we concluded.
1. In concentrated injected group (A), the GPT level was highest in first day and the increased level lasted through observation.
2. In 10:1 diluted injected group (B), the GPT level was only high above normal in first day. Thereafter, the GPT level curiously decreased below the normal, which need more study.
3. Histologic hepatic changes in A group, until 3 days, hepatic cell cord disarrary and marked hepatic cellular degeneration around the central vein were seen.
Therefater, although elevated GPT level, the hepatic changes showed only mild regenerated change
Histologic hepatic change in B group showed no remarkable change.
Above findings suggested that the liver injury was dependent on injected concentration and the hepatic injury, which was observed in early phase, appeared to be reversible.
So the hepatic injury by the Cyprinus carpio bile acid appeared complete recovery course without specific complication.
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